Is it true?
Is it serious?
Are you serious?
Are you sure?
Are you nervous?
Is it possible?
Is it wrong?
Is it right?
Is it great?
Is it true that you have cancer?
Is it true that our team lost the game?
Is it possible to borrow your pen?
I wonder if I could borrow your car.
I was wondering if I could borrow your car.
Can I use your computer?
☞ Can I ~
Do you mind if I use your pen?
Is it possible to take a day off?